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Dr. David Asch |
Research Interests
The research in my laboratory focuses on the way cells respond to different nutrient sources. I am primarily interested in the way that genes are turned on and off in response variations in their food supply. We have used the quinic acid pathway of the fungus Neurospora crassa as a model system. We are presently studying how the genes coding for the proteins of the quinic acid pathway are regulated when different carbon sources are present. We hope to extend these studies to other more medically relevant or economically fungi. In my laboratory students do basic molecular techniques such as gene cloning, gene sequencing and the polymerase chain reaction (PCR).
Selected Publications
Arnett, D.R., H.E. Lorimer, and D.K. Asch. 2009. Catabolite repression directly affects transcription of the qa-y gene of Neurospora crassa. Fungal Genetics and Biology (in press)
Battogtokh, D., D.K. Asch, M.E. Case, J. Arnold, and H.B. Schuttler. 2002. An ensemble method for identifying regulatory circuits with special reference to the qa gene cluster of Neurospora crassa. Proc. Natl. Acad. Sci. USA 99: 16904-16909.
Smiley, J. A. and D. K. Asch. 2000. Identification of a gene encoding GMP synthetase from a Neurospora crassa cDNA library by bacterial complementation. Fungal Genetics Newsletter. 47: 94-95.
Smiley, J.A., J.M. Angelot, R.C. Cannon, E. Marshall, and D.K. Asch. 1999. Radioactivity-based and spectrophotometric assays for isoorotate decarboxylase: identification of the thymidine salvage pathway in lower eukaryotes. Analytical Biochem. 266: 85-92.
Case, M. E., R. F. Geever, and D. K. Asch. 1992. Use of gene replacement transformation to elucidate gene function in the qa cluster of Neurospora crassa. Genetics 130: 729-736.